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The mitotic kinase NEK7 binds to inactive NRLP3 leading to the assembly and activation of the NLRP3 inflammasome. From left to right: apo-NEK7 (inactive), active NEK7, NE7 bound to NLRP3. Inflammasomes elicit host defense inside cells by activating caspase-1 for cytokine maturation and cell death. Dysregulation of inflammation activation can lead to cancer, autoimmune and neurodegenerative diseases. Source: PDB entries 2WQM, 6NPY

the-mitotic-kinase-nek7-binds-to-inactive-nrlp3-leading-to-the-assembly-and-activation-of-the-nlrp3

Obrázek The mitotic kinase NEK7 binds to inactive NRLP3 leading to the assembly and activation of the NLRP3 inflammasome. From left to right: apo-NEK7 (inactive), active NEK7, NE7 bound to NLRP3. Inflammasomes elicit host defense inside cells by activating caspase-1 for cytokine maturation and cell death. Dysregulation of inflammation activation can lead to cancer, autoimmune and neurodegenerative diseases. Source: PDB entries 2WQM, 6NPY fotografie, snímků a reklamní fotografie. Image 138339222.

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The Mitotic Kinase NEK7 Binds To Inactive NRLP3 Leading To The Assembly And Activation Of The NLRP3 Inflammasome. From Left To Right: Apo-NEK7 (inactive), Active NEK7, NE7 Bound To NLRP3. Inflammasomes Elicit Host Defense Inside Cells By Activating Caspase-1 For Cytokine Maturation And Cell Death. Dysregulation Of Inflammation Activation Can Lead To Cancer, Autoimmune And Neurodegenerative Diseases. Source: PDB Entries 2WQM, 6NPY Royalty Free Fotografie A Reklamní Fotografie. Image 138339222.

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